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Vasoactive Intestinal Peptide (VIP) is an acyclic neuropeptide with 28 amino acid residues. It was originally found in the gut, but has since been identified in numerous organs and tissues including the central nervous system (CNS) and peripheral nervous system (PNS). VIP is a member of the secretin/glucagon peptide family and may act as a neurotransmitter, a neuromodulator, or a hormone. More detailed information and availability can be found at https://peptide-works.com/vip/.
VIP is crucial for the regulation of immune response, inflammation and neuroprotection. It has a large effect on the health of blood vessels, since it can expand them. Thus, because of these many functions, VIP has considerable therapeutic potential. It’s a promising frontier for new medical advances, as scientists research its potential to treat auto-immune disorders, neuro-degenerative diseases such as Parkinson’s and an array of heart conditions.
Peptide Sequence (IUPAC Condensed): H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-OH
Molecular Formula: C147H237N43O43S
Molecular Weight: 3326.8 g/mol
Synonyms: Vasoactive Intestinal Peptide
View the VIP Certificate Of Analysis (COA)


The Vasoactive Intestinal Peptide (VIP), for instance, is known to exert its action via interaction with the G protein couple receptor VPAC1 and/or VPAC2 receptors on target cell membrane (Masmoudi-Kouki et al., 2007). Stimulation of adenylyl cyclase-cAMP signaling takes place downstream from this interaction resulting in an increase of intracellular cAMP.
This messenger cascade serves as the secondary messenger for many, but not all, of VIP's physiological actions. Such effects, for example, involve pronounced neuroprotection, vasodilation mediated by relaxation of smooth muscle and potent anti-inflammatory reactions due to the modulation of cytokine expression. There is also evidence that VIP regulates gastrointestinal motility and secretion, and immune cell function.
VIP has therapeutic potential in several conditions and is part of systemic homeostasic mechanisms through these actions.
Purchase VIP Peptide 2mg Australia from Peptide Works. This 99%-pure lyophilized powder comes in a resealable glass vial for maximum product lifetime.
Strong Anti-inflammatory and Immunomodulatory Effects: It is reported in literature that VIP shows strong anti-inflammatory and immunomodulatory activity, which makes it an ideal candidate for treatment of inflammatory diseases.
Further, it is reported that VIP suppresses the expression of inflammatory cytokines and chemokine in macrophages, microglia and dendritic cells as well as co-stimulatory molecules on antigen-presenting cells to regulate innate immunity. In adaptive immunity, VIP modulates Th1/Th2 balance by favoring the development and action of Th2 anti-inflammatory responses and reinforcement of Treg activity.
Research in murine models of rheumatoid arthritis indicates that VIP can decrease systemic pathogenic antibodies and inflammation. The development of new VIP analogs and delivery strategies reinforces the value of VIP as a candidate agent for personalized display to regulate immune related conditions.
Protective Lung Effects: VIP studies show powerful pulmonary protecting effects that include bronchodilation, surfactant stimulation and protection of alveolar cells. VIP is a type of neurotransmitter in the airway that relaxes smooth muscles and decreases inflammation, and has the potential to be used as a treatment for asthma and COPD. Advancement of VIP analogue, such as IK312532, and the inhaler device have advanced its clinical application.
In COVID-19 respiratory failure, the synthetic VIP Aviptadil demonstrated beneficial effects by doubling the likelihood of survival at 60 days and reduced cytokine release and respiratory distress. These results underscore the potential of VIP for preserving lung functionality, and treating acute pulmonary distress relatively safely.
Gastrointestinal Regulation: VIP Peptide has been shown through studies to have a significant role in GI regulation and strong anti–colitic properties. The peptide has been demonstrated to modulate gut motility, ion secretion, nutrient transport and release of several immune mediators, which are important for gastrointestinal homeostasis.
In a TNBS-induced colitis model, VIP diminished significantly inflammation, weight loss and intestinal damage associated to proinflammatory cytokines as TNF-alpha, IL-1 and IL-6 by inhibition of Th1-driven autoimmune responses. It has also reduced disease recurrence when applied after onset of the desease. These observations underscore VIP as therapeutic candidate in inflammatory bowel diseases such as Crohn’s disease, with prophylactic and curative effects against gut inflammation.
Metabolic effects: VIP has significant metabolic influences especially with regard to glucose and cellular energy metabolism. It has been reported to stimulate insulin release in response to glucose via VPAC2 receptors, and to promote growth of islet β-cells4^) This suggests melatonin is a potential candidate for the treatment of type 2 diabetes.
The VIP also enhances the uptake of fatty acid, metabolism of lipids and use glucose within cytotrophoblast cells, to promote placental growth and development. Although these results indicate that VIP might be a 295 FIGURE 3 Effects of intraplantar and continuous administration of VIP on body weight gain, food intake and blood glucose. beneficial agent in the treatment for metabolic diseases and pregnancy-related disorders, it short half-life precludes clinical use at present.
Cardiovascular effects: It is known that VIP has important cardiovascular actions, it is a potent vasodilatator which is 50–100 times more potent than acetylcholine. VIP increases coronary blood flow and decreases vascular resistance, myocardial contractility, and heart rate. It also 'unloads' the ventricle from the arterial pressure.
In patients with AF, increase in the concentration of serum VIP is reportedly associated with low-voltage areas (LVAs) in the LA, thus offering a non-invasive biomarker for clinical treatment. These results underscore the significance of VIP in mediating cardiovascular function, and its potential for diagnosis.
Potential Anti-Tissue Protective and Anti-Cell Death Functions: Extensive studies on VIP have documented its capabilities to be tissue protective and anti-cell death effects by immunoregulatory as well as anti-inflammatory activities. Studies in RA animal models, for example, have demonstrated a downregulation in pathogenic antibody production and increased frequency of regulatory T cells leading to amelioration of tissue injury with VIP immunomodulation.
Administration of VIP in lambs resulted in diminished levels of pro-inflammatory cytokines and lipopolysaccharide (LPS), leading to systemic anti-inflammation. Tight junction mRNA expression was not altered by VIP, however its action to reduce inflammation indicates it could have protective effects on tissues under inflammatory conditions.
Buy VIP Peptide Nasal Spray At Peptides for Sale. The spray is sold in glass bottles containing 15ml or 30ml and provides a dosage that can be easily dispensed without the need for a needle.
The frequently asked questions about VIP and their answers.
Order VIP Pre-Mixed Peptide from Peptide Works. The kit per-filled pen with 2mg cartridge - comes with a Cartridge pen and needle tips and Carry case for ease of use.
Is VIP Peptide Good for Brain Fog?
VIP peptide, meanwhile, may reduce brain fog by boosting cerebral blood flow and quelling inflammation in the brain. Some early research indicates VIP can help maintain nerve health and assist with balancing immune activity, which in turn may help promote focus and mental clarity. Some clinical reports indicate possible cognitive benefit, though rigorous human testing is thus far lacking.
Does VIP Peptide Work for Autoimmune Disorders?
The VIP peptide may be able to quiet the immune system and reduce inflammation connected with autoimmune diseases. In animals, studies show it can dampen detrimental immune responses and promote equilibrium between protective and overactive cells. Early data suggest that VIP peptide might offer benefits for inflammation control, and what specific effects is can have on immune health for those with various autoimmune forms is still under research.
What is the VIP Peptide Side Effects?
During a study, VIP peptide can also cause side effects including flushing, headache to dizziness and alterations in blood pressure. In some research models, it can influence heart rate and digestion too. Those reactions occur because VIP opens up blood vessels and affects the activity of smooth muscle. Researchers look at these effects to better understand how VIP functions in vascular, immune and nervous system function.
Is it Legal to purchase VIP Peptide?
VIP peptide is not approved for medical or therapeutic use by FDA. It is sold for research purposes only and should not be used for human or animal consumption. In the United States, it can be bought legally for research purposes under these conditions. Laws my differ in other areas, so buyers should consult their local research and import laws.

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